Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Users Online: 17337

 

Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Advertise Contacts Login 
     
ORIGINAL ARTICLE
Year : 2015  |  Volume : 56  |  Issue : 6  |  Page : 416-419

Independent and joint effects of serum 25-hydroxivitamin D and calcium on breast cancer ratio in an Iran population: Across-sectional study


1 Department of General Surgery and Environmental Health Engineering, Breast Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 Department of General Practitioner, International Campus of Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3 Department of General Practitioner, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4 Department of Biostatics and Epidemiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Correspondence Address:
Mohaddeseh Aboueian-Jahromi
Department of General Surgery and Environmental Health Engineering, Breast Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0300-1652.171621

Rights and Permissions

Background: It has been suggested that Vitamin D and calcium have protective effects against breast cancer. The results about breast cancer and serum Vitamin D and calcium levels are still controversial, indefinite, and insufficient to determine the amount of nutritional needs. Thus, we investigated the association between serum 25-hydroxyvitamin D(25-OH-D) and calcium on the ratio of breast cancer at diagnosis time. Materials and Methods: We carried out a hospital-based cross-sectional study in a population of Iran. It comprised 57 breast cancer cases, who were newly diagnosed, and 85 controls in 2013. The serum 25-OH-D and calcium levels were measured. Results: There was not any significant association between 25-OH-D and breast cancer ratio. Odds ratio (OR) comparing the highest quartile to the lowest quartile was 1.03(95% confidence interval[CI] 0.33–3.22, P-trend 0.95). Having sufficient (>75 nmol/L) serum 25-OH-D levels compared to insufficient serum 25-OH-D levels was not associated with a significantly decreased ratio of breast cancer (OR 0.55, 95% CI 0.23–1.29, P = 0.17). Furthermore, an association between calcium and breast cancer did not get statistical significance (OR 0.51, 95% CI 0.17–1.49, P-trend 0.31). The joint effect was negative interaction. Conclusion: Vitamin D and calcium do not act on decreasing ratio of breast cancer. Decreasing ratio of breast cancer in relation to serum calcium and Vitamin D level at diagnosis time needs more assessments.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4523    
    Printed164    
    Emailed0    
    PDF Downloaded18    
    Comments [Add]    
    Cited by others 3    

Recommend this journal