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REVIEW ARTICLE
Year : 2013  |  Volume : 54  |  Issue : 6  |  Page : 371-375

Aetio-pathogenesis of breast cancer


Department of Trauma and Orthopaedic Surgery, Leeds University Teaching Hospital, Leeds, United Kingdom

Correspondence Address:
Imran Haruna Abdulkareem
Department of Trauma and Orthopaedic Surgery, B Floor Clarendon Wing, Leeds General Infirmary, Leeds-LS1 3EX, West Yorkshire
United Kingdom
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0300-1652.126284

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This is a literature review on the aetiology and pathogenesis of breast cancer, which is the most common cancer worldwide, and the second leading cause of cancer death, especially in Western countries. Several aetiological factors have been implicated in its pathogenesis, and include age, genetics, family history, diet, alcohol, obesity, lifestyle, physical inactivity, as well as endocrine factors. These factors act separately or together in the causation of breast cancer. More recently, triple negative breast cancer has been described in certain categories of patients and is associated with poorer prognosis and earlier recurrence compared with the conventional breast cancer. Therefore, adequate knowledge of these factors is important in identifying high risk groups and individuals, which will help in screening, early detection and follow-up. This will help to decrease the morbidity and mortality from this life-threatening disease.


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